Job Details:

“Process Sciences Engineer”, sought by Beam Therapeutics, Inc. (“Beam” or “Beam Therapeutics”), headquartered at 238 Main Street, Cambridge, MA 02142.  This would also be the primary worksite for the role long-term.  Note that it is a permanent, immediately available, job opportunity that does not require any travel. It is an in-house, laboratory-based position. One must therefore live in the City of Cambridge, MA, or within a reasonable, daily commuting distance thereof (e.g., areas contemplated can include the City of Boston, the larger Greater Boston region, or Massachusetts’ MetroWest, North or South Shore communities). This is because, again, the role works full-time from Beam headquarters (see the corporate address in Cambridge, MA, given above). That requires the person filling the role to live locally in Greater Boston. Telecommuting from home, note, to be clear, is not available for and in this laboratory-based team and role. Traditional job description, it now follows.

This role, note, at Beam, works principally on lipid nanoparticle (“LNP”) manufacturing. It reports to Beam’s Director of LNP Development. Working under this Beam Therapeutics leader, note that the role focuses on scale-up and optimization of lipid nanoparticles, supporting the delivery of base editors (fundamental to Beam science and innovation). Within Beam’s team of LNP Development professionals, the position contributes to development and scaling of a manufacturing process, having the lofty and attainable goal of bringing in-vivo base editing to patients in need. Role works on process manufacturing, optimization and nanoparticle formulation; large biomolecule production; aseptic unit operations for sterile drug product manufacture; frozen and lyophilized formulations for clinical-stage drug product; and it also designs and executes experiments to optimize nanoparticle formulation and manufacturing processes deployed, including in the area of tangential-flow filtration and mixing. Role executes other laboratory-based experiments, supporting a robust, reproducible process, underlying key manufacture of clinical trial materials used at Beam. It also designs and executes laboratory experiments used to evaluate and optimize stability of drug product; supports development of automated processes for LNP manufacturing across mixing geometries, scales, components and payloads; engages in technology transfer exercises, both within the company and externally, as a subject-matter expert in the area of LNP drug product manufacturing; contributes to related process development initiatives involving change controls, process deviations, and writes material focused on promoting quality engineering excellence; supports data aggregation and analysis of corporate LNP manufacturing, having again both internal and external applications, in order to effectively define process characterization, optimization and control activities, used and deployed; contributes to generating high-quality documentation for scientific-focused, Standard Operating Procedures, applied at Beam Therapeutics; and contributes to generating high-quality, scientific content in support of regulatory filings, made and advanced by Beam.                 

Full-time position requiring a Bachelor’s Degree or foreign equivalent in bioengineering, biomedical engineering, chemistry, chemical engineering, pharmaceutical sciences, or related field. It also requires the possession of five years of the following progressive, post-baccalaureate experience: (a) applying Current Good Manufacturing Practices regarding large biomolecule production and aseptic unit operations for sterile drug product manufacture; (b) engaging in LNP process development or manufacturing; and (c) manufacturing frozen or lyophilized formulations in support of clinical-stage drug product.

Note that in lieu of the above, one may alternatively qualify for this role with a Master’s Degree, or its foreign equivalent, in bioengineering, biomedical engineering, chemistry, chemical engineering, pharmaceutical sciences, or related field. Where the individual is Master’s-qualified, the person must also in this event then possess two years of the following experience: (a) applying Current Good Manufacturing Practices regarding large biomolecule production and aseptic unit operations for sterile drug product manufacture; (b) engaging in LNP process development or manufacturing; and (c) manufacturing frozen or lyophilized formulations in support of clinical-stage drug product. 

How to Apply:

Applicants should send resumes directly to employer.  May specifically apply directly to job posting for the role found on the “Careers” page to our website at https://beamtx.com/careers/.  All submissions will be promptly reviewed.

Beam Therapeutics, Inc.